2021.09.16 17:54 dem0n0cracy Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse -- Forty-eight mice were divided into 4 groups: low-fat or 3 high fat diets (HFD, 45% kcals from fat) with LA comprising 1%, 15%, and 22.5% of kilocalories, the balance being saturated fat
Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse
Kyle J. Mamounis,1,2 Ali Yasrebi,1 and Troy A. Roepke1,2,3,*Author information Copyright and License information DisclaimerThe publisher's final edited version of this article is available at J Nutr BiochemSee other articles in PMC that cite the published article.Go to:
Abstract A significant change in the Western diet, concurrent with the obesity epidemic, was a substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA). Despite increasing investigation on type as well as amount of fat, it is unclear which fatty acids are most obesogenic. The objective of this study was to determine the obesogenic potency of LA vs. saturated fatty acids, and the involvement of hypothalamic inflammation. Forty-eight mice were divided into 4 groups: low-fat or 3 high fat diets (HFD, 45% kcals from fat) with LA comprising 1%, 15%, and 22.5% of kilocalories, the balance being saturated fatty acids. Over 12 weeks, bodyweight and composition, food intake, calorimetry, and glycemia assays were performed. Arcuate nucleus and blood were collected for mRNA and protein analysis. All HFD-fed mice were heavier and less glucose tolerant than control. 22.5% LA caused greater bodyweight gain, decreased activity and insulin resistance compared to control and 1% LA. All HFDs elevated leptin and decreased ghrelin in plasma. Neuropeptides gene expression was higher in 22.5% HFD. The inflammatory gene Ikk was suppressed in 1% and 22.5% LA. No consistent pattern of inflammatory gene expression was observed, with suppression and augmentation of genes by one or all of the HFDs relative to control. These data indicate that in male mice, LA induces obesity and insulin resistance, and reduces activity, more than saturated fat, supporting the hypothesis that increased LA intake may be a contributor to the obesity epidemic.
Keywords: obesity, HFD, hypothalamic inflammation, saturated fat, PUFA, linoleic acid
submitted by dem0n0cracy to StopEatingSeedOils [link] [comments]
2021.09.16 17:54 ItsQuackingGood Xbox Game Pass
oh wow, can't believe Xbox Game Pass has over 100 great games on console and PC with day-in-date Xbox Game Studios releases like Forza Horizon 5 & Halo Infinite coming this year, I'm getting hyped just thinking about it 🥲 😍
submitted by ItsQuackingGood to copypasta [link] [comments]
2021.09.16 17:54 thejajangman Who is the biggest douchebag on the men's tour?
2021.09.16 17:54 Colleen_HM_ Hemlock Varnish Shelf? New to identifying mushrooms!
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2021.09.16 17:54 JustJessJ_Art Candiace Doubles Down on Body Shaming Ashley
|submitted by JustJessJ_Art to RHOP [link] [comments]|
2021.09.16 17:54 hannahbeliever Bandit has clearly had a hard and tiring day
2021.09.16 17:54 keeks38 How does natural light blonde hair change with age?
2021.09.16 17:54 nowitsgiven Worried about putting BTC on a hardware wallet... thoughts?
I think my biggest concern with putting my BTC on a hardware wallet is due to the possibility of losing it as it is a tangible thing like a USB that could easily be misplaced...
Quick side question - with the key words they give you, could I retrieve my BTC at a later date IF I lost the physical wallet ?
submitted by nowitsgiven to BitcoinBeginners [link] [comments]
2021.09.16 17:54 silenthill02  Looking for a conversation
2021.09.16 17:54 RVAIsTheBestCity 30 Richmond employees are on unpaid leave for not complying with vaccine mandate set for October 1st
Out of approximately 3600 Richmond city employees, only 30 are currently suspended for not abiding by the vaccination mandate. 360 employees were exempted for religious reasons. So we're talking almost 85% who've gotten at least the first dose of the vaccine and well over 90% who've either gotten vaccinated or agreed to regular testing/masking mandates to avoid vaccination. So much for all the sqwaking. I also have heard Chief Smith has effectively commanded his officers get vaccinated after there was some union pushback. Not sure how many are among the suspended 30 but at the end of the day, we've seen this consistently: Mandates work. https://richmond.com/news/local/30-richmond-employees-are-on-unpaid-leave-for-not-complying-with-vaccine-mandate-360-applied/article_6b283f5f-9cf9-5d52-b1d2-505e1145aaa0.html#tracking-source=home-top-story
submitted by RVAIsTheBestCity to rva [link] [comments]
2021.09.16 17:54 yourlonglostmom Does downtown Scranton have red light cameras?
2021.09.16 17:54 svanapps Attackers Use Cryptomining Malware to Target Organizations
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2021.09.16 17:54 DonPittelleone Collegue started to eat a box of pringles everyday and uses the lid to draw art.
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2021.09.16 17:54 GabeDoesNotTalk Should I pay off my student loans?
I’ve got about $2,000 left in student loans and enough to pay them off. Would it be better for my credit to keep the student loans open and pay them off over time for payment history and credit mix or just pay them off now?
As far as other credit: I’ve got a BofA and a Citi with no balances $1500 and $3000 credit limit respectively. BofA is 4 years old and Citi is less than 1 year. Never missed a payment always paid full balance off.
submitted by GabeDoesNotTalk to CRedit [link] [comments]
2021.09.16 17:54 LookBoo2 Did they just call their product a potato?
I apologize since this is probably against Rule 3 in some ways, but I didn't know if advertisements are considered proper threads.
My friends used to call bad computers a potato(or a toaster) like someone was running the game on a potato. I get they are probably trying to say upgrade from a potato like a slow part, but this sounds like they were using the old saying "you say po-tay-to, I say pot-ah-to". If I understand that old phrase correctly the meaning is "we are saying the same thing just said differently".
Am I missing something, or is this just a really bad way to advertise? I swear I am not trying to just feign ignorance for a laugh, I assume that since I am a bit older there must be some kind of new meme or pc joke I don't get.
submitted by LookBoo2 to pcmasterrace [link] [comments]
2021.09.16 17:54 Ok_River_9125 🤬 AngryDoge 🤬 Just launched! Great marketing plans coming! 7% Reflection in XRP! 100% safe project! 🚀
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Renounced Ownership: https://bscscan.com/token/0x8bc72e1b19e88836dc156107740a9c36a07a3992#readContract
submitted by Ok_River_9125 to CryptoMarsShots [link] [comments]
2021.09.16 17:54 jjg301 Add ADA token to Metamask Harmony wallet
2021.09.16 17:54 ShadowSlayer222 Kengan Omega: Sequel to Markiplier's "Meow" Vid
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2021.09.16 17:54 Ok-Taste6104 🌍🌍 Mini Floki 💎Low MC Gem💎 FLOKI Rewards! 💣
💣🚨MiniFloki just launched a few hours ago and is a low MC gem with an awesome
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submitted by Ok-Taste6104 to CryptoMoon [link] [comments]
2021.09.16 17:54 PepeBabinski Derek Chauvin to be arraigned for alleged civil rights violation
2021.09.16 17:54 teleportmepls 16f looking for ppl that want to chat regularly!
I live in California and am looking for friends in USA timezones that want a long term chat partner!
Making a low effort post like this seems to get more attention than a detailed one so here it is lol In my experience ppl either put too much in their posts or too little in chats.
I'll be in distance learning just hiding my phone under the desk so stop by and say hello!
submitted by teleportmepls to MeetNewPeopleHere [link] [comments]
2021.09.16 17:54 Imaginarybreaker Heaven Cancelor The First Person To See Through Touma's Lie - Toaru Majutsu no Index
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2021.09.16 17:54 Puzzleheaded-Gas-906 Mars space train station, Evgeny Bondarenko/me, Gouache, 2020
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2021.09.16 17:54 Anime_axe anime_best_moments
|submitted by Anime_axe to anime_best_moments [link] [comments]|
2021.09.16 17:54 kovalevv I just can't stop drawing her
|submitted by kovalevv to JahySamaWaKujikenai [link] [comments]|